HIF/HIF Prolyl-Hydroxylase Degrader

HIF/HIF Prolyl-Hydroxylase Isoform Comparison

HIF/HIF Prolyl-Hydroxylase Degrader (1):

Cat. No.	Product Name	Effect	Purity

HY-168641

PROTAC HIF-1α degrader-1	Degrader
PROTAC HIF-1α degrader-1 (compound V2) is a potent hypoxia-inducible factor-1α (HIF-1α) PROTAC degrader with an IC₅₀ value of 7.54 µM. PROTAC HIF-1α degrader-1 shows anti-proliferative activity. PROTAC HIF-1α degrader-1 decreases the HIF-1α protein expression. PROTAC HIF-1α degrader-1 induces apoptosis. (Pink: ligand for target protein (HY-111387); black: linker (HY-W013731); Blue: E3 ligase ligand (HY-112078)).

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